Cell-based microfluidic devices allows us to understand real cells’ responses to biological simuli, thus drawing more realistic diagnostic conclusions. They are therefore a valuable tool in drug screening, cytokine detection, and cellomics. In this study, we increase the cell-trapping density and enable resettability by carefully design the geometry of the micropost trapping array. The array is designed such that cells are immoblized between the microposts during forward flow, and released during backward flow. The geometry of the posts were tuned such that 80% of single-cell trapping with a 91% of cell-cell contact was achieved.
Sochol, R., Iwai, K., Higa, A., Lo, J., Zhou, E., Lo, L., Luong, C., Dueck, M., Li, S., Lee, L., Lin, L., A Resettable High-Density Microfluidic Cell Trapping System, Proceedings of the 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS 2010), Groningen, The Netherlands